3-(2-chloro-4-pyrimidinyl)-Benzoicacid synthesis
1synthesis methods
- Product Name:3-(2-chloro-4-pyrimidinyl)-Benzoicacid
- CAS Number:937271-47-1
- Molecular formula:C11H7ClN2O2
- Molecular Weight:234.64
Yield:937271-47-1 63%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in 1,2-dimethoxyethane at 80;Inert atmosphere;Alkaline aq. solution;Suzuki coupling;
References:
William, Anthony D.;Lee, Angeline C.-H.;Goh, Kee Chuan;Blanchard, Stéphanie;Poulsen, Anders;Teo, Ee Ling;Nagaraj, Harish;Lee, Chai Ping;Wang, Haishan;Williams, Meredith;Sun, Eric T.;Hu, Changyong;Jayaraman, Ramesh;Pasha, Mohammed Khalid;Ethirajulu, Kantharaj;Wood, Jeanette M.;Dymock, Brian W. [Journal of Medicinal Chemistry,2012,vol. 55,# 1,p. 169 - 196] Location in patent:experimental part