3-(2-METHYLPHENYL)PROPIOPHENONE synthesis

13synthesis methods

Product Name:3-(2-METHYLPHENYL)PROPIOPHENONE
CAS Number:84839-91-8
Molecular formula:C16H16O
Molecular Weight:224.3

2-Propen-1-one, 3-(2-methylphenyl)-1-phenyl-

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84839-91-8
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Yield:84839-91-8 96%

Reaction Conditions:

with bis[dichlorido(η⁵-1,2,3,4,5-pentamethyl-cyclopentadienyl)rhodium (III)] in isopropanol at 100; for 12 h;Inert atmosphere;Sealed tube;

Steps:

2. Typical Procedure

General procedure: To an oven-dried vial, chalcone 1 (0.20 mmol, 1.0 equiv), [(Cp*RhCl2)2] (0.006 mmol, 3.0 mol %), and isopropanol (1.0 mL) were added. The vial was charged with N2 and sealed immediately. The mixture was stirred at 100 °C, and the progress of the reaction was monitored by TLC. After the completion of the reaction, the mixture was cooled down to room temperature, filtered through a celite pad, and washed with ethyl acetate. The filtrate was concentrated in vacuo and the residue was purified by column chromatography on silica gel or preparative thin-layer chromatography to obtain the desired products 2 (petroleum ether : ethyl acetate = 100:1).

References:

Yu, Xuewen;Wan, Saihong;Zhou, Wang [Synlett,2022] Location in patent:supporting information