3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE synthesis
- Product Name:3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE
- CAS Number:70988-04-4
- Molecular formula:C11H11NO3
- Molecular Weight:205.21
1116-98-9
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20469-65-2
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82102-37-2
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70988-04-4
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Yield:70988-04-4 77%
Reaction Conditions:
Stage #1: cyanoacetic acid tert-butyl ester;1-bromo-3,5-dimethoxybenzene;9-methyl-9H-fluorene-9-carbonyl chloridewith dichloro(1,5-cyclooctadiene)palladium(II);N-Methyldicyclohexylamine;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;magnesium chloride;tri tert-butylphosphoniumtetrafluoroborate in 1,4-dioxane at 100; for 18 h;Glovebox;Inert atmosphere;
Stage #2: with formic acid in 1,4-dioxane;Inert atmosphere;
References:
Jensen, Mikkel T.;Juhl, Martin;Nielsen, Dennis U.;Jacobsen, Mikkel F.;Lindhardt, Anders T.;Skrydstrup, Troels [Journal of Organic Chemistry,2016,vol. 81,# 4,p. 1358 - 1366]
