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ChemicalBook CAS DataBase List 3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoate
24088-59-3

3-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoate synthesis

6synthesis methods
-

Yield:24088-59-3 87%

Reaction Conditions:

in 1,4-dioxane at 200; for 0.166667 h;

Steps:

48.a

Example 48; 4-[3-(3-Phenyl-l,2,4-oxadiazol-5-yl)propanoyl]aminothiophene-3-carboxylic Add; a) 3-(3-Phenyl-l,2,4-oxadiazol-5-yl)propanoic Acid; To N'-hydroxybenzenecarboximidamide (1.00 g, 7.34 mmol) in 1,4-dioxane (4 mL, EPO 50 mmol) was added succinic anhydride (735 mg, 7.34 mmol). The reaction was heated to 200 °C for 600 s. After cooling to room temperature, the reaction mixture was purified via Combi-flash. to give the desired product (1.4 g, 87%).

References:

WO2007/15744,2007,A1 Location in patent:Page/Page column 63-64

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