3,4,5-TRIPHENYL-1,2,4-TRIAZOLE synthesis
- Product Name:3,4,5-TRIPHENYL-1,2,4-TRIAZOLE
- CAS Number:4073-72-7
- Molecular formula:C20H15N3
- Molecular Weight:297.35
Yield:4073-72-7 96%
Reaction Conditions:
with ammonium cerium (IV) nitrate at 80; for 1 h;Time;Reagent/catalyst;
Steps:
3,4,5-Triphenyl-4H-1,2,4-triazole (3a);Typical Procedure
General procedure: A mixture of amidrazone 1a (1.00 g, 0.0047 mol), benzaldehyde (2a)(0.50 g, 0.0047 mol), PEG-300 (5 mL) and CAN (5 mol%) was heated at 80 °C for 1 h (Table 2). After completion of the reaction as monitored by TLC, the mixture was cooled to r.t. and extracted with Et2O (3 × 20mL). The combined organic layers were washed with H2O (2 × 30 mL) and aq NaHCO3 solution (2 × 30 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude residue was purified by silica gel column chromatography (EtOAc-hexane, 1:1) to afford pure 3a.
References:
Nakka, Mangarao;Tadikonda, Ramu;Rayavarapu, Srinuvasarao;Sarakula, Prasanthi;Vidavalur, Siddaiah [Synthesis,2015,vol. 47,# 4,art. no. SS-2014-N0460-OP,p. 517 - 525]
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