3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE synthesis

6synthesis methods

Product Name:3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE
CAS Number:50971-75-0
Molecular formula:C20H27N3
Molecular Weight:309.45

1H-Isoindole-1,3(2H)-dione, 2-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-

93358-79-3
0 suppliers
inquiry

3-(4-BENZHYDRYL-1-PIPERAZINYL)-1-PROPANAMINE

50971-75-0
5 suppliers
$180.00/1g

Yield:50971-75-0 67%

Reaction Conditions:

with hydrazine hydrate in ethanol at 80; for 5 h;

Steps:

11

Weigh accurately obtained above was dissolved in 40mLEtOH S38 740mg 1.69mmol about, and after stirring and dissolving 0.5ml of hydrazine hydrate was added dropwise thereto, placed in 80 ° C oil bath for 5h, TLC detection, after completion of the reaction, cooling , the reaction system was filtered, residue discarded, the filtrate was collected, the filtrate was concentrated on silica gel column chromatography chromatography using elution system containing 1% triethylamine, eluent petroleum ether and ethyl acetate in a volume ratio of : 1 gradient elution was carried out to give 350mg of compound S39 , yield 67.0%

References:

CN103524413,2016,B Location in patent:Paragraph 0154; 0155; 0156; 0160

841-77-0 Synthesis