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3-(4-FLUORO-PHENYL)-3-FURAN-2-YL-PROPYLAMINE synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 80 percent / tris(4-methoxyphenyl)phosphine; dimethylcarbonate / Pd(OAc)2 / H2O; tetrahydrofuran / 24 h / 40 °C
2: 86 percent / NaH / tetrahydrofuran / 15 h / 0 - 20 °C
3: 36 percent / H2; cc.HCl / Pd/C / methanol / 15 h / 20 °C / 2250.18 - 3000.24 Torr

References:

Martyres, Domnic;Schmiedt, Frank [Tetrahedron Letters,2006,vol. 47,# 10,p. 1649 - 1651]

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