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4-Fluorobenzoic acid

4-Fluorobenzoic acid structure

CAS No.: 456-22-4

Chemical Name:: 4-Fluorobenzoic acid

Synonyms: PFBA;P-FLUOROBENZOIC ACID;potassium 2,2,3,3,3-pentafluoropropanoate;4-fluoro-benzoicaci;The acid;AKOS 92636;p-Fluorobenzoic;fluorobenzoicacid;Fluoro benzoic ac;4-Fluorbenzoesure

CBNumber:: CB4853637

Molecular Formula:: C7H5FO2

Molecular Weight:: 140.11

MDL Number:: MFCD00002530

MOL File:: 456-22-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:15

Product description	Number	Pack Size	Price
p-Fluorobenzoic acid NIST?SRM?	NIST2143	2g	$839
4-Fluorobenzoic acid 98%	128384	5g	$19.5
4-Fluorobenzoic acid 98%	128384	25g	$38.4
4-Fluorobenzoic Acid >98.0%(GC)(T)	F0112	25g	$41
4-Fluorobenzoic acid 99%, purified by sublimation	418846	1g	$44.8
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4-Fluorobenzoic acid Properties

Melting point	182-184 °C (lit.)
Boiling point	117 °C
Density	1.479
storage temp.	Sealed in dry,Room Temperature
solubility	alcohol: soluble
form	Crystalline Powder
pka	4.15(at 25℃)
color	White to slightly yellow
Water Solubility	Soluble in alcohol, hot water, methanol, and ether. Very slightly soluble in cold water.
Merck	14,4171
BRN	1906922
InChI	1S/C7H5FO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)
InChIKey	BBYDXOIZLAWGSL-UHFFFAOYSA-N
SMILES	OC(=O)c1ccc(F)cc1
CAS DataBase Reference	456-22-4(CAS DataBase Reference)
FDA UNII	V5ROO2HOU4
NIST Chemistry Reference	Benzoic acid, 4-fluoro-(456-22-4)
EPA Substance Registry System	Benzoic acid, 4-fluoro- (456-22-4)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

22-41-36/37/38

Safety Statements

26-39-24/25-22-37/39-36

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29163900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2

NFPA 704

	0
2		0

4-Fluorobenzoic acid price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	NIST2143	p-Fluorobenzoic acid NIST?SRM?	456-22-4	2g	$839	2026-04-30	Buy
Sigma-Aldrich	128384	4-Fluorobenzoic acid 98%	456-22-4	5g	$19.5	2026-04-30	Buy
Sigma-Aldrich	128384	4-Fluorobenzoic acid 98%	456-22-4	25g	$38.4	2026-04-30	Buy
TCI Chemical	F0112	4-Fluorobenzoic Acid >98.0%(GC)(T)	456-22-4	25g	$41	2026-04-30	Buy
Sigma-Aldrich	418846	4-Fluorobenzoic acid 99%, purified by sublimation	456-22-4	1g	$44.8	2026-04-30	Buy

Product number	Packaging	Price	Buy
NIST2143	2g	$839	Buy
128384	5g	$19.5	Buy
128384	25g	$38.4	Buy
F0112	25g	$41	Buy
418846	1g	$44.8	Buy

4-Fluorobenzoic acid Chemical Properties,Uses,Production

Description

4-Fluorobenzoic acid is used as an intermediate in organic synthesis. For instance, it is used to synthesize N-cuccinimidyl 4-[18F]-fluorobenzoate, which is used for the ¹⁸F labeling of antibodies. It has been used in high resolution charge density study.

Reference

AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorobenzoic acid has been used in high resolution charge density study.

Definition

ChEBI: A fluorobenzoic acid carrying a fluoro substituent at position 4.

Purification Methods

Crystallise the acid from 50% aqueous EtOH, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333, 9 III 1327, 9 IV 953.]

4-Fluorobenzoic acid synthesis

Synthesis of 4-Fluorobenzoic acid from 4-Fluorobenzyl alcohol

4-Fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Benzocaine Ethyl 4-fluorobenzoate 4-Fluorobenzaldehyde Fluoroboric acid STANDARD BUFFER

N-Benzylhydroxylamine hydrochloride

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Preparation Products

Lomefloxacin 4-Fluorobenzoyl chloride (4-(4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL)PHENYL)METHANOL 4-Fluorobenzyl chloride 4-Fluoro-2-methylbenzoic acid

4-Fluoro-3-nitrobenzoic acid 4-FLUOROBENZOIC ANHYDRIDE 1(3H)-ISOBENZOFURANONE, 5-FLUORO- 2-(4-Fluorophenyl)-pyrrolidine 4-FLUORO-3-METHYLBENZOIC ACID

N-(2,2-Dichloro-1-hydroxyethyl)-4-fluorobenzamide N,N-Bis(2-chloroethyl)-p-fluorobenzylamine

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4-Fluorobenzoic acid Suppliers

Global( 620)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	923	55
EAST STAR BIOTECH (SUZHOU) CO., LTD.	+8617706846989	marketing@eaststarbio.com	China	48	58
SHANGHAI YOUNG-CHEM CHEMICAL CO., LTD.	+8613817489192	hebe@ychemchemical.com	China	2435	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8736	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58

Supplier	Advantage
Speranza Chemical Co., Ltd.	55
EAST STAR BIOTECH (SUZHOU) CO., LTD.	58
SHANGHAI YOUNG-CHEM CHEMICAL CO., LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai UCHEM Inc.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58

4-Fluorobenzoic Acid: Applications in Radiosynthesis and Antimicrobial Research
4-Fluorobenzoic acid, a bacterial metabolite, is pivotal in radiopharmacy for automated synthesis of [18F]FBA and derivatives.
Apr 22，2025

View Lastest Price from 4-Fluorobenzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-30	4-Fluorobenzoic acid 456-22-4	US $38.00 / kg	1kg	0.99	100kg	Shanghai UCHEM Inc.
2026-04-30	4-Fluorobenzoic acid 456-22-4	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-04-30	4-Fluorobenzoic acid 456-22-4	US $15.00 / KG	1KG	99%	300MT/year	Speranza Chemical Co., Ltd.

4-Fluorobenzoic acid
456-22-4
US $38.00 / kg
0.99
Shanghai UCHEM Inc.

4-Fluorobenzoic acid
456-22-4
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

4-Fluorobenzoic acid
456-22-4
US $15.00 / KG
99%
Speranza Chemical Co., Ltd.

4-Fluorobenzoic acid Spectrum

4-Fluorobenzoic acid(456-22-4)MS 4-Fluorobenzoic acid(456-22-4)¹HNMR 4-Fluorobenzoic acid(456-22-4)¹³CNMR 4-Fluorobenzoic acid(456-22-4)IR1 4-Fluorobenzoic acid(456-22-4)IR2 4-Fluorobenzoic acid(456-22-4)Raman

456-22-4(4-Fluorobenzoic acid)Related Search:

4-Fluorobenzonitrile Stearic acid 4-Bromofluorobenzene Folic acid 4-Fluorobenzamide

4-Fluorobenzaldehyde 4-Fluoroanisole Florfenicol 4-(4-Fluorobenzoyl)butyric acid Methyl 4-fluorobenzoate

2,6-Difluorobenzoic acid Ethyl 4-fluorobenzoate Transfluthrin Ethyl 2-(Chlorosulfonyl)acetate 2,4,5-Trifluorobenzoic acid

4-Fluorobenzyl alcohol Citric acid Ascoric Acid

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4-FLUOROBENZOIC ACID AKOS 92636 Benzoic acid, p-fluoro- Benzoicacid,4-fluoro- fluorobenzoicacid para-Fluorobenzoic acid p-Fluorobenzoic Acid 4-Fluorobenzoic Acid 4-Fluorobenzoi acid 4-FLUOROBENZOIC ACID, SUBLIMED, 99% 4-FLUOROBENZOIC ACID, FOR ELEMENTAL ANALYSIS P-FLUOROBENZOIC ACID GRADE I 4-Fluorobenzoicacid,98% TIMTEC-BB SBB008568 RARECHEM AL BO 0053 p-Fluorobenzoic p-Fluorobenzoicacid,min.97% 4-Fluorobenzoic acid ,99% p-Fluorobenzoic acid, min. 97% 4-Fluorobenzoic acid, 99% 25GR 4-FLUOROBENZOIC ACID FOR SYNTHESIS Fluoro benzoic ac The acid 4-Fluorobenzoic acid 99%, purified by sublimation Haloperidol Impurity 14 4-FluorobenzoicAcid> 4-Fluorbenzoesure 4-Fluorobenzoic Acid pure, 98% 4-fluoro-benzoicaci potassium 2,2,3,3,3-pentafluoropropanoate 13C6]-4-Fluorobenzoic acid p-Fluorobenzoic acid - Fluorine PFBA P-FLUOROBENZOIC ACID 456-22-4 FC6H4COOH Organic Building Blocks C7 Carbonyl Compounds Carboxylic Acids Building Blocks CARBOXYLIC ACID carboxylic acid| alkyl Fluorine Carboxylic Acids Phenyls & Phenyl-Het C7 Carbonyl Compounds Benzene derivatives Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Carboxylic Acids Phenyls & Phenyl-Het Fluorobenzene API intermediates Fluorin-contained Benzoic acid series bc0001