(3,5-Dichloro-phenyl)-acetic acid methyl ester synthesis
- Product Name:(3,5-Dichloro-phenyl)-acetic acid methyl ester
- CAS Number:55954-24-0
- Molecular formula:C9H8Cl2O2
- Molecular Weight:219.06
1196155-85-7
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55954-24-0
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Yield:55954-24-0 91%
Reaction Conditions:
with water in toluene; for 1 h;
Steps:
1.A1b Step Alb: Preparation of methyl 3,5-dichlorobenzeneacetate
To methyl 3,5-dichlorobenzeneethanimidate hydrochloride ( 1: 1) (i.e. the product from Step Ala) (50 g, 0.107 mol) was added to a mixture of toluene (167 mL) and water (167 mL). After 60 min the organic phase was removed, dried (MgS04), and evaporated to give the title compound as an oil (39 g, 91%). NMR (DMSO-i) δ ppm 3.63 (s, 3H), 3.77 (s, 2H), 7.38 (d, 2H), 7.52 (t, 1H).
References:
WO2013/90547,2013,A1 Location in patent:Page/Page column 33
67-56-1
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55954-24-0
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