(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)ACETIC ACID synthesis

6synthesis methods

Product Name:(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)ACETIC ACID
CAS Number:32710-88-6
Molecular formula:C13H14N2O2
Molecular Weight:230.26

1H-Pyrazole-4-acetic acid, 3,5-dimethyl-1-phenyl-, ethyl ester

32710-86-4
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(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)ACETIC ACID

32710-88-6
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Yield:32710-88-6 86%

Reaction Conditions:

with sodium hydroxide in ethanol;water;

Steps:

1.b EXAMPLE 1

(b) 3.5 grams of the 3,5-dimethyl-1-phenylpyrazol-4-acetic acid ethyl ester obtained in Example (1a) above, 1.0 gram sodium hydroxide, 10 milliliters water and 10 milliliters ethanol were mixed and the mixture heated to boiling temperature under reflux for 15 minutes. The pH of the solution thus obtained was adjusted till it reached a value of 9-10. Thereafter the alcohol was distilled off and the aqueous solution was extracted with ether or benzene and the aqueous solution was clarified by treatment with activated carbon. After acidifying the clear aqueous solution with hydrochloric acid, 2.7 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetic acid, melting at 137°-139° C. were obtained, representing a yield of 86%. After recrystallization from a mixture of water and methanol, the acid melted at 138°-139° C.

References:

US4146721,1979,A

1H-Pyrazole-4-acetonitrile, 3,5-dimethyl-1-phenyl-

32710-90-0
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32710-88-6
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References

123-54-6 Synthesis

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32710-88-6
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References

116423-03-1
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32710-88-6
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References

1H-Pyrazole, 4-(chloromethyl)-3,5-dimethyl-1-phenyl-

1152595-49-7
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32710-88-6
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References