3,5-DIMETHYL-4-ISOXAZOLECARBOXAMIDE synthesis
- Product Name:3,5-DIMETHYL-4-ISOXAZOLECARBOXAMIDE
- CAS Number:74356-30-2
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
Yield:74356-30-2 98%
Reaction Conditions:
Stage #1: 4-bromo-3,5-dimethyl-1,2-oxazolewith diisobutylaluminium hydride;magnesium;lithium chloride;zinc(II) chloride in tetrahydrofuran at 23;Inert atmosphere;
Stage #2: Trichloroacetyl isocyanate in tetrahydrofuran at -20 - 25;Inert atmosphere;
Stage #3: with methanol;potassium carbonate in tetrahydrofuran at 25; for 12 h;Inert atmosphere;
References:
Schade, Matthias A.;Manolikakes, Georg;Knochel, Paul [Organic Letters,2010,vol. 12,# 16,p. 3648 - 3650] Location in patent:supporting information; experimental part
31301-45-8
148 suppliers
$13.43/250mgs:
74356-30-2
42 suppliers
inquiry