3,5-ditert-butyl-4'-nitro[1,1'-biphenyl]-4-ol synthesis
- Product Name:3,5-ditert-butyl-4'-nitro[1,1'-biphenyl]-4-ol
- CAS Number:15138-30-4
- Molecular formula:C20H25NO3
- Molecular Weight:327.42
Yield:15138-30-4 92%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide;acetonitrile;
Steps:
1 Synthesis of 2,6-di-tert-butyl-4-(4-nitrophenyl)phenol
EXAMPLE 1 Synthesis of 2,6-di-tert-butyl-4-(4-nitrophenyl)phenol 8.40 g (40.7 mmol) 2,6-di-tert-butylphenol was dissolved in 100 ml dried DMSO. 8 g (58 mmol) potassium carbonate and 8.5 g (54 mmol) p-chloronitrobenzene were added into the DMSO solution. The DMSO solution was heated to 100~120° C. for 12 hrs with stirring. Then the reaction mixture was allowed to cool to room temperature and poured into distilled water. The aqueous solution was acidified to pH 2~4 and yellow precipitate was collected by filtration. The yellow precipitate was washed with water and dried. The crude yield was 92%. The yellow precipitate was purified by recrystallizing in cyanomethane, mp 157~160° C. Elemental Anal. Calcd.: C, 73.40; H, 7.64; N, 4.28. Found: C, 73.25; H, 7.58; N, 4.25%.
References:
US7317110,2008,B2
1310-73-2
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