ChemicalBook CAS DataBase List 3，7-dichloro-8-chloro methyl quinoline

3，7-dichloro-8-chloro methyl quinoline synthesis

3synthesis methods

Product Name:3，7-dichloro-8-chloro methyl quinoline
CAS Number:84086-96-4
Molecular formula:C10H6Cl3N
Molecular Weight:246.52

3，7-dichloro-8-chloro methyl quinoline's preparation method is to put 7-chloro-8-methylquinoline and o-dichlorobenzene in the reactor, and add catalyst azobisisobutyronitrile, heat up, pass chlorine gas, and control unreacted quinoline with gas chromatography, The content is less than or equal to 1%. Precipitation and recovery of o-dichlorobenzene give a mixture of 3,7-dichloro-8-chloromethylquinoline.

78941-93-2
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95-50-1
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Yield:84086-96-4 93%

Reaction Conditions:

with 2,2'-azobis(isobutyronitrile);chlorine

Steps:

1 EXAMPLE 1

EXAMPLE 1 89 parts of 7-chloro-8-methylquinoline and 0.5 part of azobisisobutyronitrile were introduced into 500 parts of dichlorobenzene and the mixture was heated to 140° C. Introduction of 80 parts of chlorine was started at this temperature the temperature being increased to 160° C. during this operation. After the addition of chlorine, the solution was flushed with nitrogen, most of the solvent was distilled off and the precipitated solid was filtered off with suction and washed with petroleum ether. 113 parts of 3,7-dichloro-8-chloromethylquinoline of melting point 129° C. were obtained. The yield corresponds to 93% of theory.

References:

US4497651,1985,A

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$110.00/2g

84086-96-4
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References

87-60-5 Synthesis

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