3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE synthesis
- Product Name:3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE
- CAS Number:27314-97-2
- Molecular formula:C7H6N4O2
- Molecular Weight:178.15
480-96-6
200 suppliers
$10.00/1g
420-04-2
379 suppliers
$15.00/25g
27314-97-2
154 suppliers
$45.00/10mg
Yield:27314-97-2 60%
Reaction Conditions:
Stage #1:benzofurazan oxide;CYANAMID with sodium hydroxide in methanol;water at 60; for 4 h;
Stage #2: with acetic acid; pH=5 - 8
Steps:
1 Preparation of 3-amino-1,2,4-benzotriazine-1,4-diazonium oxide
Benzofurazan weighed 27.2g (0.2 mol) and 25.2g solid Cyanamide(NH2CN, 0.6 mol) was placed in a 500 ml three-necked flask and dissolved in 200 ml of 50% aqueous methanol solution.Stir and slowly add sodium hydroxide 48g (1.2mol) until sodium hydroxide is added.The reaction was placed in a 60°C water bath and TLC traced the reaction until the end of the reaction (4 h). During the reaction, the solution slowly turned purple-black, cooled, filtered, and the filter cake was dissolved in an appropriate amount of water and then filtered. The mother liquor was collected and acidified with acetic acid. The pH is 5-8, the red solid material is obtained, DMF is crystallized and recrystallized, filtered, and dried to obtain the target compound 24.5g, yield 60%
References:
The Chinese People's Liberation Army Military Academy Of Medical Sciences Radioactive And Radiation Medical Institute;Huang Rongqing;Xiao Bingkun;Yang Jianyun;Ding Rui;Wu Gang CN102887869, 2018, B Location in patent:Paragraph 0041-0043
5424-06-6
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$50.00/50mg
27314-97-2
154 suppliers
$45.00/10mg
20028-80-2
24 suppliers
$165.00/500mg
27314-97-2
154 suppliers
$45.00/10mg
88-74-4
27 suppliers
$10.00/1g
27314-97-2
154 suppliers
$45.00/10mg
1493-27-2
523 suppliers
$5.00/10g
27314-97-2
154 suppliers
$45.00/10mg