ChemicalBook CAS DataBase List 3-AMINO-1-BENZYLPYRROLIDINE-3-CARBOXYLIC ACID

3-AMINO-1-BENZYLPYRROLIDINE-3-CARBOXYLIC ACID synthesis

5synthesis methods

Product Name:3-AMINO-1-BENZYLPYRROLIDINE-3-CARBOXYLIC ACID
CAS Number:145602-87-5
Molecular formula:C12H16N2O2
Molecular Weight:220.27

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3-AMINO-1-BENZYLPYRROLIDINE-3-CARBOXYLIC ACID

145602-87-5
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$61.00/100mg

Yield:145602-87-5 83.8%

Reaction Conditions:

with barium dihydroxide in water; for 36 h;Inert atmosphere;Reflux;

Steps:

1 Example 1: Synthesis of 3-amino-1-benzylpyrrolidine-3-carboxylic acid

1-Benzylpyrrolidin-3-one (8.76 g, 0.05 mol), potassium cyanide (5.86 g, 0.09 mol) and ammonium carbonate (50.7 g, 0.65 mol) were added to 50% ethanol (135 mL) and heated to reflux 3 hours. Ethanol is distilled off under normal pressure, and the residue is cooled and crystallized, and filtered.3-Amino-1-benzylpyrrolidine-3-carbonitrile (8.09 g, 80.4%) was obtained as a brown powder.The compound obtained above and barium hydroxide (63.40 g, 0.37 mol) were added to water (300 mL) under a nitrogen atmosphere and heated to reflux for 36 hours. After cooling to room temperature, water (100 mL) was added and the pH was adjusted to 3 with 6 mol/L sulfuric acid (about 100 mL). Filtration, adding triethylamine (about 40 mL) to the filtrate to adjust to pH=6, standing for crystallizing, filtering, and drying the cake to obtain a brown powdery solid 3-amino-1-benzylpyrrolidine-3-carboxylic acid (7.42 g, 83.8%).

References:

CN108117545,2018,A Location in patent:Paragraph 0016