3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID synthesis
- Product Name:3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- CAS Number:376592-93-7
- Molecular formula:C13H11NO3
- Molecular Weight:229.23
376591-95-6
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376592-93-7
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Yield:376592-93-7 96.9%
Reaction Conditions:
with ferric hydroxide;hydrazine hydrate in ethanol;water at 20 - 50; for 3.5 h;Solvent;Temperature;Reagent/catalyst;
Steps:
1-3; 1-9 Example 2 Preparation of Eltrombopag Intermediate
Dissolve 77.76g of 2'-hydroxy-3'-nitrobiphenyl-3-carboxylic acid in a mixed solvent of 130mL of water and 648mL of ethanol, add 2.33g of ferric hydroxide and 7.78g of silica gel, mix well, and control the temperature for 20-30 Add 233 mL of hydrazine hydrate at , control the temperature and stir for 30 minutes, increase the temperature to 50 and react for 3 hours, and then drop to room temperature after the reaction is complete;After filtration, the filtrate was added with formic acid to adjust the pH to 4.5, stirred for 2 hours, filtered, washed with a small amount of ethanol, and dried to obtain 66.64 g of Eltrombopag intermediate, with a yield of 96.9%, a purity of 99.8%, and a maximum single impurity of 0.10%.
References:
CN112552194, 2021, A Location in patent:Paragraph 0039-0072
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25487-66-5
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695-96-5
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688363-79-3
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376592-93-7
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$18.00/100mg