3-AMINO-3-(2,4-DIFLUORO-PHENYL)-PROPIONIC ACID synthesis
- Product Name:3-AMINO-3-(2,4-DIFLUORO-PHENYL)-PROPIONIC ACID
- CAS Number:412925-23-6
- Molecular formula:C9H9F2NO2
- Molecular Weight:201.17
141-82-2
740 suppliers
$5.00/25g
1550-35-2
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$6.00/5g
412925-23-6
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$110.00/0.5g
Yield:-
Reaction Conditions:
with ammonium acetate in ethanol at 80; for 16 h;
Steps:
137.1
Step 1 : To a stirred solution of 2,4-difluorobenzaldehyde (10.0 g, 70.4 mmol, 1 equiv), malonic acid (8.78 g, 84.45 mmol, 1.2 equiv) and ammonium acetate (10.84 g, 140.8 mmol, 2 equiv) in EtOH (100 mL) was heated at 80°C for 16 h. The solid was filtered off and washed with n-pentane to give the 3-amino-3-(2,4-difluorophenyl)propanoic acid as off white solid (1 1.5 g, crude). LC-MS (ES) m/z = 202.1 [M+H] +
References:
WO2017/46737,2017,A1 Location in patent:Page/Page column 137