(S)-2-AMINO-3-(2,3-DIFLUORO-PHENYL)-PROPIONIC ACID synthesis

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 90 percent / NaOEt / ethanol / 2 h / Heating
2: 2M NaOH / methanol; H₂O / 3 h / 40 °C
3: 92 percent / p-xylene / 2 h / Heating
4: Aspergillus genus acylase; 0.2 M AcONa; 0.2 M NaOH / H₂O / 48 h / 38 °C / pH 8.0

References:

Fujita, Tsugumi;Nose, Takeru;Matsushima, Ayami;Okada, Kazushi;Asai, Daisuke;Yamauchi, Yasuko;Shirasu, Naoto;Honda, Takeshi;Shigehiro, Daiki;Shimohigashi, Yasuyuki [Tetrahedron Letters,2000,vol. 41,# 6,p. 923 - 927]