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3-amino-5-phenylfuran-2-carbonitrile synthesis

3synthesis methods
3-amino-5-phenylfuran-2-carbonitrile

237435-85-7
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: 98 percent / PBr3 / 48 h / 170 °C
2.1: MgSO4; NaH / tetrahydrofuran / 1 h
2.2: 90 percent / tetrahydrofuran / 1 h / 20 °C

References:

Norman;Chen;Chen;Fotsch;Hale;Han;Hurt;Jenkins;Kincaid;Liu;Lu;Moreno;Santora;Sonnenberg;Karbon [Journal of Medicinal Chemistry,2000,vol. 43,# 22,p. 4288 - 4312]