3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID synthesis
- Product Name:3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
- CAS Number:58327-75-6
- Molecular formula:C8H6N2O2S
- Molecular Weight:194.21
![ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE](/CAS/GIF/52505-46-1.gif)
52505-46-1
91 suppliers
$20.00/1g
58327-75-6
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$45.00/100mg
Yield:58327-75-6 98%
Reaction Conditions:
with water;sodium hydroxide in ethanol at 70; for 0.75 h;
Steps:
2 acid 238
To a solution of 237 (20.0 g, 90.1 mrnol) in EtOH (500 mL) and water (500 mL) is added NaOH (7.2 g. 180 mmoi) in portions. After stirring at 70 °C for 45 minutes, the mixture is cooled to 0 °C and is acidified with concenirated HC1 to pH 5. The yellow solid is then collected by filtration and dried to give 238 (17 g, 98% yield). (MS: [M±Hj 195.2)
References:
WO2017/176812,2017,A1 Location in patent:Paragraph 0508
6602-54-6
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$6.00/10g
58327-75-6
47 suppliers
$45.00/100mg
52505-45-0
44 suppliers
$243.88/1gm:
58327-75-6
47 suppliers
$45.00/100mg