3-BENZYL-5-(CHLOROMETHYL)-1,2,4-OXADIAZOLE synthesis
- Product Name:3-BENZYL-5-(CHLOROMETHYL)-1,2,4-OXADIAZOLE
- CAS Number:51802-77-8
- Molecular formula:C10H9ClN2O
- Molecular Weight:208.64
67-56-1
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$9.00/25ml
140-29-4
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$19.00/25mL
51802-77-8
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$45.00/25mg
19227-11-3
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$29.00/1g
Yield:-
Reaction Conditions:
with hydroxylamine hydrochloride;sodium carbonate in ethanol;
Steps:
15.A 3-benzyl-5-chloromethyl-1,2,4-oxadiazole
A. A solution of 117.2 g. (1 mole) of phenylacetonitrile and 69.5 g. (1 mole) of hydroxylamine hydrochloride in 500 ml. of aqueous ethanol is treated with 106 g. of sodium carbonate. The mixture is then heated to 50°C. and held at this temperature for two days. After cooling, the sodium chloride which forms is filtered off and the solvent is removed in vacuo. Upon recrystallization of the crystalline residue from aqueous methanol, colorless needles of phenylacetamide oxime having a m.p. of 55°-60°C. are obtained.
References:
US3956498,1976,A