3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE synthesis
- Product Name:3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE
- CAS Number:1001054-49-4
- Molecular formula:C20H30N2
- Molecular Weight:298.4656
![3-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE](/CAS/GIF/189333-49-1.gif)
189333-49-1
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Yield:-
Reaction Conditions:
Stage #1: 3-benzyl-3,9-diazaspiro[5.5]undecane;cyclobutanonewith acetic acid in dichloromethane at 0; for 0.5 h;
Stage #2: with sodium tris(acetoxy)borohydride in dichloromethane at 20;
Steps:
1.A.4
3-Benzyl-3,9-diazaspiro[5.5]undecane (6.14 mmol) is dissolved in 2.5% acetic acid in DCM (24 mL) at 0° C. and treated dropwise with cyclobutanone (9.21 mmol). The mixture is stirred for 30 min and then sodium triacetoxyborohydride (9.21 mmol) is added in portions. The reaction mixture is stirred at rt overnight, basified with saturated sodium carbonate solution and extracted with DCM. The combined extracts are washed with water, and then brine, dried over anhydrous Na2SO4 and concentrated in vacuo to afford the title compound. LC-MS (Method 1)=299.19; RT=1.26 min.
References:
US2008/247964,2008,A1 Location in patent:Page/Page column 29
3612-20-2
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![9-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE-2,4-DIONE](/CAS/GIF/CB11501822.gif)
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![9-benzyl-2,4-dioxo-3,9-diazaspiro[5.5]undecane-1,5-dicarbonitrile](/CAS2/GIF/189333-46-8.gif)
189333-46-8
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