3-Bromo-4-chloropyridine synthesis
- Product Name:3-Bromo-4-chloropyridine
- CAS Number:36953-42-1
- Molecular formula:C5H3BrClN
- Molecular Weight:192.44
![4-CHLOROFURO[3,2-C]PYRIDINE](/CAS/GIF/31270-80-1.gif)
31270-80-1
119 suppliers
$10.00/100mg
36953-42-1
270 suppliers
$6.00/1g
![3-Bromo-4-chlorofuro[3,2-c]pyridine](/CAS/GIF/220939-72-0.gif)
220939-72-0
41 suppliers
$62.00/250mg
Yield:36953-42-1 96%
Reaction Conditions:
with sodium hydroxide;bromine in methanol;tetrachloromethane
Steps:
543.A 3-bromo-4-chlorofuro[3,2-c]pyridine
EXAMPLE 543A 3-bromo-4-chlorofuro[3,2-c]pyridine A solution of 4-chlorofuro[3,2-c]pyridine (commercially available, 10.60 g, 69 mmol) in carbon tetrachloride (135 mL) was cooled to -15° C. and bromine (12.13 g, 80 mmol) was added drop-wise over a fifteen minute time period. The mixture was stirred at ambient temperature for eighteen hours. The solvent was removed in vacuo, and the residue was dissolved in methanol (250 mL). A solution of 20% aqueous sodium hydroxide (35 mL) was added and the mixture was stirred 1 hour at ambient temperature. The methanol was removed in vacuo, and the residue was partitioned between water (100 mL) and dichloromethane (50 mL). The combined organic layers were dried over anhydrous magnesium sulfate and the solvent was removed in vacuo to give 3-bromo-4-chloro[3,2-c]pyridine 15.45 g, 96%) as a solid. MS (ESI(+)) m/e 232, 234 (M+H)+.
References:
Betschmann, Patrick;Burchat, Andrew F.;Calderwood, David J.;Curtin, Michael L.;Davidsen, Steven K.;Davis, Heather M.;Frey, Robin R.;Heyman, Howard R.;Hirst, Gavin C.;Hrnciar, Peter;Michaelides, Michael R.;Muckey, Melanie A.;Rafferty, Paul;Wada, Carol K. US2005/26944, 2005, A1
13626-17-0
109 suppliers
$5.00/100mg
36953-42-1
270 suppliers
$6.00/1g
1678-49-5
137 suppliers
$31.00/1 g
36953-42-1
270 suppliers
$6.00/1g
626-55-1
577 suppliers
$5.00/5 / G
36953-42-1
270 suppliers
$6.00/1g
462-08-8
487 suppliers
$14.00/25g
36953-42-1
270 suppliers
$6.00/1g