3-Bromo-5-(1-pyrrolidinyl)-pyridine synthesis
- Product Name:3-Bromo-5-(1-pyrrolidinyl)-pyridine
- CAS Number:944718-19-8
- Molecular formula:C9H11BrN2
- Molecular Weight:227.1
123-75-1
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944718-19-8
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Yield:944718-19-8 73.6%
Reaction Conditions:
at 100; for 16 h;Microwave irradiation;
Steps:
1 11272] Preparation of 3-bromo-5-(pyrrolidin-1 -yl)pyridine (LI) is depicted below in Scheme 8.
Step 1
To a microwave vial was added 3,5-dibromopyridine (XLIX) (2.0 g, 8.44 mmol) and pyrrolidine (L) (3.0 g, 42.2 mmol).
The reaction was microwaved at 100° C. for 16 h.
The crude mixture was purified by chromatography on silica gel (hexanes:EtOAc=4:1) to afford 3-bromo-5-(pyrrolidin-1-yl)pyridine (LI) (1.41 g, 6.21 mmol, 73.6% yield) as a white solid. ESIMS found for C9H11BrN2 m/z 228.9 (M+H).
References:
US2015/266825,2015,A1 Location in patent:Paragraph 1272; 1273
123-75-1
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233770-01-9
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944718-19-8
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$45.00/50mg