3-Bromo-5-(3-chlorophenoxy)pyridine synthesis
- Product Name:3-Bromo-5-(3-chlorophenoxy)pyridine
- CAS Number:28232-65-7
- Molecular formula:C11H7BrClNO
- Molecular Weight:284.54
625-92-3
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Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: potassium; copper / isopropyl alcohol / 14 h / 140 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Cooling with ice
2.2: 48 h / 100 °C
References:
Breining, Scott R.;Melvin, Matt;Bhatti, Balwinder S.;Byrd, Gary D.;Kiser, Melanie N.;Hepler, Christopher D.;Hooker, Dawn N.;Zhang, Jenny;Reynolds, Leslie A.;Benson, Lisa R.;Fedorov, Nikolai B.;Sidach, Serguei S.;Mitchener, J. Pike;Lucero, Linda M.;Lukas, Ronald J.;Whiteaker, Paul;Yohannes, Daniel [Journal of Medicinal Chemistry,2012,vol. 55,# 22,p. 9929 - 9945]
