3-Bromo-5-ethoxybenzoic acid synthesis
- Product Name:3-Bromo-5-ethoxybenzoic acid
- CAS Number:855198-27-5
- Molecular formula:C9H9BrO3
- Molecular Weight:245.07
1229442-68-5
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855198-27-5
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Yield:855198-27-5 97%
Reaction Conditions:
with sodium hydroxide in methanol; for 3 h;
Steps:
2 Step 2: 3-bromo-5-ethoxybenzoic acid
To a solution of ethyl 3-bromo-5-ethoxybenzoate (5 g, 18.3 mmol) in methanol (18.3 ml) was added sodium hydroxide (2 M, 9.15 ml, 18.3 mmol) and the reaction stirred for 3hours. The organics were removed in vacuo and the remaining solution extracted with ethyl acetate. The layers were separated and the aqueous phase adjusted to pH 4 by the addition of 2 M HCI and then extracted twice with ethyl acetate. The combined organic extracts were washed with brine then dried and concentrated to give the title compound as a white solid (3.44 g, 97 % yield). MS (mlz) 247.0 (M+2).
References:
WO2017/6295,2017,A1 Location in patent:Page/Page column 116; 122
1180016-48-1
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855198-27-5
25 suppliers
$115.00/500mg
140472-69-1
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855198-27-5
25 suppliers
$115.00/500mg
64-67-5
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140472-69-1
176 suppliers
$19.00/250mg
855198-27-5
25 suppliers
$115.00/500mg