3-Bromo-6-methyl-2-(trifluoromethyl)pyridine synthesis
- Product Name:3-Bromo-6-methyl-2-(trifluoromethyl)pyridine
- CAS Number:1211517-98-4
- Molecular formula:C7H5BrF3N
- Molecular Weight:240.02
3430-13-5
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$5.00/5g
39971-65-8
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1211517-98-4
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1211591-90-0
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Yield:1211517-98-4 25% ，1211591-90-0 14%
Reaction Conditions:
with tert.-butylhydroperoxide;bis-(((isopropyl)sulfinyl)oxy)zinc;zinc sulfinate in chloroform;water at 20 - 50; for 20 h;Overall yield = 39 %; Overall yield = 43 %Spectr.; regioselective reaction;
References:
O'Hara, Fionn;Blackmond, Donna G.;Baran, Phil S. [Journal of the American Chemical Society,2013,vol. 135,# 32,p. 12122 - 12134] Location in patent:supporting information