ChemicalBook CAS DataBase List 3-Bromobenzonitrile

3-Bromobenzonitrile synthesis

12synthesis methods

Product Name:3-Bromobenzonitrile
CAS Number:6952-59-6
Molecular formula:C7H4BrN
Molecular Weight:182.02

3132-99-8 Synthesis

3132-99-8
475 suppliers
$5.00/10g

6952-59-6
349 suppliers
$9.00/10g

Yield:6952-59-6 89%

Reaction Conditions:

with ammonium acetate;phenyltrimethylammonium tribromide in acetonitrile at 20; for 16 h;

Steps:

General procedure: to a solution of 2-pyridinecarbaldehyde 1 (54 mg, 0.5 mmol) and ammonium acetate (385mg, 5.0 mmol) in MeCN )6ml), was added trimethylphenylammonium tribromide (376 mg, 1.0 mmol) at room temperature. after stirring for 21 h at rt, the reaction mixture was treated with 0.5 M aq Na2S2O3(10 ml), 1.0 M NaHCO3 )15 ml) and extracted with EtOAc (60 mL). The organic layer was washed with 0.5 M Na2S2O3 and successively washed with saturated aq.NaCl, and dried over MgSO4.

References:

Sayama, Shinsei [Heterocycles,2016,vol. 92,# 10,p. 1796 - 1802]

FullText

15852-73-0 Synthesis