3-Bromobenzyl alcohol synthesis
- Product Name:3-Bromobenzyl alcohol
- CAS Number:15852-73-0
- Molecular formula:C7H7BrO
- Molecular Weight:187.03
3132-99-8
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$5.00/10g
15852-73-0
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$11.00/25g
Yield:15852-73-0 99.8%
Reaction Conditions:
with sodium tetrahydroborate in ethanol at 20 - 25;
Steps:
49 (3-Bromophenyl)methanol
Example 49 (3-Bromophenyl)methanol Sodium borohydride (7.1 g, 186.1 mmol) in several portions was added to a solution of 3-bromobenzaldehyde (114.8 g, 620.4 mmol) in EtOH (650 mL) at 25° C. Then the mixture was stirred for 1 h at room temperature. The reaction was quenched with water (200 mL). After removing EtOH, the residue was dissolved in AcOEt (500 mL), and filtered. The filtrate was washed with water (150 mL), brine (150 mL), and dried over Na2SO4. After removing the solvent, 115.8 g of the title compound was obtained (yield: 99.8%).
References:
Glaxo Group Limited US2009/203657, 2009, A1 Location in patent:Page/Page column 54
618-89-3
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15852-73-0
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$11.00/25g
24398-88-7
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15852-73-0
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585-76-2
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$6.00/5g
15852-73-0
280 suppliers
$11.00/25g
591-17-3
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$10.00/10g
3132-99-8
502 suppliers
$5.00/10g
585-76-2
362 suppliers
$6.00/5g
15852-73-0
280 suppliers
$11.00/25g