ChemicalBook CAS DataBase List 3-Bromobenzyl alcohol

3-Bromobenzyl alcohol synthesis

7synthesis methods

Product Name:3-Bromobenzyl alcohol
CAS Number:15852-73-0
Molecular formula:C7H7BrO
Molecular Weight:187.03

3132-99-8 Synthesis

3132-99-8
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15852-73-0
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$11.00/25g

Yield:15852-73-0 99.8%

Reaction Conditions:

with sodium tetrahydroborate in ethanol at 20 - 25;

Steps:

49 (3-Bromophenyl)methanol
Example 49 (3-Bromophenyl)methanol Sodium borohydride (7.1 g, 186.1 mmol) in several portions was added to a solution of 3-bromobenzaldehyde (114.8 g, 620.4 mmol) in EtOH (650 mL) at 25° C. Then the mixture was stirred for 1 h at room temperature. The reaction was quenched with water (200 mL). After removing EtOH, the residue was dissolved in AcOEt (500 mL), and filtered. The filtrate was washed with water (150 mL), brine (150 mL), and dried over Na₂SO₄. After removing the solvent, 115.8 g of the title compound was obtained (yield: 99.8%).

References:

Glaxo Group Limited US2009/203657, 2009, A1 Location in patent:Page/Page column 54

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618-89-3 Synthesis