3-Bromomethylbenzenesulfonamide synthesis
- Product Name:3-Bromomethylbenzenesulfonamide
- CAS Number:220798-52-7
- Molecular formula:C7H8BrNO2S
- Molecular Weight:250.11
220798-42-5
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220798-52-7
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Yield:220798-52-7 94%
Reaction Conditions:
with phosphorus tribromide in dichloromethane at 20;
Steps:
7 Preparation example 7Preparation of 3-(bromomethyl)benzenesulfonamide, (XII-1)
1.48 g (7.90 mmol)) 3-(hydroxymethyl)benzenesulfonamide were suspended in 25 ml dichloromethane and 2.35 g (8.69 mmol) phosphorus tribromide were added at 20 °C. The mixture was stirred overnight. Water was added carefully and the organic phase separated. The aqueous phase was two times extracted with dichloromethane. The combined organic phases were washed with brine, dried over magnesium sulfate and concentrated in vacuo.Yield: 1.9 g (94 %) 3-(bromomethyl)benzenesulfonamide as raw product, which was pure enough for the next step.
References:
WO2015/7668,2015,A1 Location in patent:Page/Page column 144
4025-64-3
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220798-52-7
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636-76-0
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220798-52-7
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65-85-0
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220798-52-7
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$51.00/100mg