3-CHLORO-2-METHOXYBENZALDEHYDE synthesis
- Product Name:3-CHLORO-2-METHOXYBENZALDEHYDE
- CAS Number:223778-54-9
- Molecular formula:C8H7ClO2
- Molecular Weight:170.59
869088-29-9
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223778-54-9
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Yield: 92%
Reaction Conditions:
with manganese(IV) oxide in dichloromethane at 20 - 45; for 20.5 h;
Steps:
61
Manganese dioxide (16 g, 184 mmol) was added to a solution of the product of preparation 58 (5.68 g, 33 mmol) in dichloromethane (300 mL) and the mixture was heated for 45° C. for 2.5 hours and at room temperature for 18 hours. The mixture was then filtered through Arbocel, washing through with dichloromethane, and the filtrate was concentrated in vacuo to afford the title compound as a yellow oil in 92% yield, 5.2 g. 1H NMR (CDCl3, 400 MHz) δ: 4.02(s, 3H), 7.19(m, 1H), 7.63(d, 1H), 7.79(d, 1H), 10.40(s, 1H).
References:
Fish, Paul Vincent;MacKenny, Malcolm Christian;Stobie, Alan;Wakenhut, Florian;Whitlock, Gavin Alistair US2005/250775, 2005, A1 Location in patent:Page/Page column 32
1927-94-2
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223778-54-9
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1927-94-2
154 suppliers
$6.00/250mg
75-05-8
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223778-54-9
85 suppliers
$11.00/250mg