3-CHLORO-4-DIFLUOROMETHOXY-PHENYLAMINE synthesis
- Product Name:3-CHLORO-4-DIFLUOROMETHOXY-PHENYLAMINE
- CAS Number:39211-55-7
- Molecular formula:C7H6ClF2NO
- Molecular Weight:193.58
40319-63-9
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39211-55-7
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Yield:39211-55-7 90 %
Reaction Conditions:
with platinum on carbon;hydrogen in methanol at 25; under 775.743 Torr;
Steps:
Step 2.3-Chloro-4-(difluoromethoxy)aniline
To a mixture of 2-chloro-1-(difluoromethoxy)-4-nitro-benzene (3.00 g, 13.4 mmol) in methanol (40.0 mL) was added platinum on carbon (0.70 g, 2.68 mmol, 3 wt. % loading) under hydrogen. The mixture was stirred at 25 °C for 2 hr under hydrogen (15 psi). On completion, the reaction mixture was filtered through a pad of Celite and the filtrate was concentrated in vacuo to give 3-chloro-4-(difluoromethoxy)aniline (2.6 g, 13.5 mmol, 90%) as a brown oil. m/z ES+ [M+H]+194.1.
References:
WO2022/266458,2022,A1 Location in patent:Paragraph 0845; 0847-0848
619-08-9
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39211-55-7
38 suppliers
$174.00/1g