Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Novaluron
116714-46-6

Novaluron synthesis

3synthesis methods
The industrial synthesis of novaluron begins with the preparation of a key intermediate: 3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]aniline. This intermediate is synthesised via an etherification reaction between trifluoromethoxytrifluoroethylene and 2-chloro-4-aminophenol, forming the complex fluorinated aromatic structure. The resulting aniline derivative is then acylated with 2,6-difluorobenzoyl chloride to form the benzoylphenyl backbone. Finally, the compound undergoes urea formation through reaction with isocyanates or carbodiimides, yielding the active novaluron molecule. These reactions are typically carried out in organic solvents such as acetonitrile or dichloromethane under controlled temperature and pH conditions to ensure high yield and purity.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 98 percent / KOH / toluene; dimethylsulfoxide / 3 h / 0 °C
2: 82 percent / Heating

References:

Andriollo, Nunzio;Barino, Luisa;Meazza, Giovanni;Rama, Franco;Scordamaglia, Raimondo;Caprioli, Vincenzo [Gazzetta Chimica Italiana,1992,vol. 122,# 5-7,p. 253 - 259]

Novaluron Related Search: