3-Chloro-6-Methoxypyrazin-2-aMine synthesis

Yield:13484-56-5 52%

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide at 20; for 16 h;

Steps:

1 Step 1 - Synthesis of 3-chloro-6-methoxypyrazin-2-amine:

To a solution of 6-methoxypyrazin-2-amine (3 g, 24 mmol) in dry DMF (35 mL), N-chlorosuccinimide (3.2 g, 24 mmol) was added. The reaction mixture was stirred at room temperature for 16 h then waspoured into ice and brine (130 mL). The aqueous solution was extracted with ethyl acetate (3 x 120 mL), the organic phase was washed with 5% solution of LiCI, dried over Na2SO4 and evaporated under reduced pressure. The crude was purified by SNAP-340-NH (cyclohexane/ethyl acetate from 95:5 up to 8:2) and by SNAP1 00-Si-OH (eluting with DCM)to afford the title intermediate (1.98 g, 12.5 mmol, 52% yield). LC-MS (M-H) = 160.1

References:

WO2017/211759,2017,A1 Location in patent:Page/Page column 84; 85