3-CHLORO-N-(4-ETHOXYPHENYL)PROPANAMIDE synthesis

Yield:19314-15-9 86%

Reaction Conditions:

with sodium carbonate in ethyl acetate at 50; for 3 h;

Steps:

2.1

1) 68.5 g of p-ethoxyaniline, 75 g of sodium carbonate, added to 500 ml of ethyl acetate,65 g of a solution of 3-chloropropionyl chloride in ethyl acetate was slowly added dropwise, and the reaction was kept at 50 ° C for 3 hours.After cooling to room temperature, the reaction solution was neutralized with dilute hydrochloric acid, the organic phase was separated, concentrated, and cooled to precipitate a solid.Filtration, washing with water, drying the solid to obtain a pink solid N-(4-ethoxyphenyl)-3-chloroacrylamide 94 g, yield 86%;

References:

CN108383781,2018,A Location in patent:Paragraph 0037