3'-CHLOROBIPHENYL-4-YLAMINE synthesis
- Product Name:3'-CHLOROBIPHENYL-4-YLAMINE
- CAS Number:5748-36-7
- Molecular formula:C12H10ClN
- Molecular Weight:203.67
63503-60-6
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106-40-1
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5748-36-7
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Yield:5748-36-7 75%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);sodium carbonate in ethanol;water;toluene;Inert atmosphere;Reflux;Suzuki coupling;
Steps:
Biphenyl-4-ylamine (35a)
General procedure: To a stirred solution of 4-bromoaniline (0.69g, 4 mmol) in 40 mL of toluene was added Pd(Ph3P)4 (0.32 g, 0.28 mmol), a solution of sodium carbonate (2.54 g, 24 mmol) in water (20 mL) and a solution of phenylboronic acid (0.98 g, 8 mmol) in EtOH (20 mL) under nitrogen atmosphere. The reaction mixture was stirred vigorously under reflux overnight and cooled, water was added and the reaction mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were dried and concentrated to provide brown solid which was flash chromatographed on silica gel eluting with 30% EtOAc in hexanes to provide 0.18 g (27%) of 35a
References:
Venkatraj, Muthusamy;Messagie, Jonas;Joossens, Jurgen;Lambeir, Anne-Marie;Haemers, Achiel;Van Der Veken, Pieter;Augustyns, Koen [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 4,p. 1557 - 1568] Location in patent:supporting information; experimental part
952-22-7
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5748-36-7
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![[1,1'-Biphenyl]-4-amine, 3-chloro-4'-nitro-](/CAS/20210305/GIF/28402-09-7.gif)
28402-09-7
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5748-36-7
30 suppliers
$342.30/1G