ChemicalBook CAS DataBase List 3-CHLOROPHENETOLE

3-CHLOROPHENETOLE synthesis

4synthesis methods

Product Name:3-CHLOROPHENETOLE
CAS Number:2655-83-6
Molecular formula:C8H9ClO
Molecular Weight:156.61

108-43-0 Synthesis

108-43-0
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$13.00/5g

75-03-6
355 suppliers
$11.00/5g

2655-83-6
22 suppliers
$1123.70/10ML

Yield:-

Reaction Conditions:

Stage #1: 3-monochlorophenolwith sodium hydride in tetrahydrofuran at 20; for 0.166667 h;
Stage #2: ethyl iodide in tetrahydrofuran;

Steps:

7.13.13; 13

To a solution of 60% NaH (0.373 g,9.34 mmol) in THF (20 mL), phenol (1 g, 7.78 mmol) was added dropwise at room temperature. The mixture was stirred at room temperature for 10 min. and then ethyl iodide (1.27 g, 8.17 mmol) was added. The solution was stirred overnight. The reaction mixture was poured into water and extracted twice with diethyl ether. The combined organic layers, were washed with water, saturated brine, dried over Na₂SO₄, filtered, and concentrated under reduced pressure to afford 13.1 as colorless oil.

References:

WO2008/137027,2008,A2 Location in patent:Page/Page column 72