3-ETHYL-3-(3-HYDROXYPHENYL)-1-METHYLAZEPAN-2-ONE synthesis
- Product Name:3-ETHYL-3-(3-HYDROXYPHENYL)-1-METHYLAZEPAN-2-ONE
- CAS Number:71556-74-6
- Molecular formula:C15H21NO2
- Molecular Weight:247.33
71556-72-4
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Yield:71556-74-6 81.4%
Reaction Conditions:
with boron tribromide in dichloromethane at 0; for 3.5 h;
Steps:
3 Embodiment 3: preparation of compoundIII:
The 0.5g compound II dissolved in 15 ml anhydrous DCM (dichloromethane), will 1.44g boron tribromide soluble in 4mLDCM (dichloromethane) is applied to the above-mentioned reaction solution. Cooling to 0 °C reaction 3.5h rear, using saturated NaHCO3solution to adjust pH to 5-6, separating, the aqueous phase used 10mLDCM extraction, combined with the phase, using anhydrous NaSO4drying, was eventually 0.385g white solid (yield 81.4%).
References:
CN105801483,2016,A Location in patent:Paragraph 0025; 0030; 0031
87887-10-3
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71556-74-6
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71592-44-4
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75-03-6
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2556-73-2
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71556-74-6
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