3'-fluoro-3'-deoxyadenosine synthesis
- Product Name:3'-fluoro-3'-deoxyadenosine
- CAS Number:75059-22-2
- Molecular formula:C10H12FN5O3
- Molecular Weight:269.23
51754-99-5
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Yield:-
Steps:
Multi-step reaction with 9 steps
1: 100 percent / Ag2O / dimethylformamide / 24 h / Ambient temperature
2: 92 percent / acetic acid / H2O / 1 h / 50 °C
3: 95 percent / imidazole / dimethylformamide / 3 h / 0 °C
4: 106.8 g / 2,6-lutidine / CH2Cl2 / 2 h / 0 °C
5: 58 percent / tetrabutylammonium fluoride / tetrahydrofuran / 7 h / 0 °C
6: H2 / 5percent Pd/C / ethanol / 24 h
7: pyridine / 24 h / Ambient temperature
8: 1.) 30percent HBr, 2.) Hg(CN)2 / 1.) AcOH, Ac2O, RT; 4 h, 2.) nitromethane, reflux, 1 h
9: 90 percent / NaOMe / methanol / 1 h / Heating
References:
Morizawa;Nakayama;Yasuda;Uchida [Bulletin of the Chemical Society of Japan,1989,vol. 62,# 6,p. 2119 - 2120]
112668-60-7
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75059-22-2
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205109-12-2
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14980-09-7
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![(1S,2R,4S,5S)-2-((benzyloxy)methyl)-4-methoxy-3,6-dioxabicyclo[3.1.0]hexane](/CAS/20200401/GIF/14645-49-9.gif)
14645-49-9
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75059-22-2
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