3-FLUOROTHIOANISOLE synthesis
- Product Name:3-FLUOROTHIOANISOLE
- CAS Number:658-28-6
- Molecular formula:C7H7FS
- Molecular Weight:142.19
624-92-0
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658-28-6
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Yield: 45% ， 30%
Reaction Conditions:
with potassium tert-butylate in acetonitrile at 50; for 6 h;Sealed tube;
Steps:
4.2.1. Synthetic procedures
General procedure: Aryl fluorides (1.0 mmol), CH3SSCH3 (1.2 mmol), t-BuOK (3.0 mmol) and CH3CN (2 mL) were taken in a 25-ml sealed tube. The reaction mixture was stirred at 50 C for 6 h under air. After cooling to room temperature, the product was diluted with H2O (5 mL) and extracted with EtOAc (4 × 10 mL). The extracts were combined and washed by brine (3 × 10 mL), dried over MgSO4, filtered, and evaporated, and purified by chromatography on silica gel to obtain the desired products with ethyl acetate/hexane (v/v = 1:301:100). The products were characterized by their spectral and analytical data and compared with those of the known compounds (See supporting information).
References:
Huang, Dayun;Wu, Xiangmei [Journal of Fluorine Chemistry,2021,vol. 245,art. no. 109778]
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658-28-6
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33733-73-2
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658-28-6
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625-98-9
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658-28-6
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