3-HYDROXYCYCLOBUTANECARBOXYLIC ACID synthesis
- Product Name:3-HYDROXYCYCLOBUTANECARBOXYLIC ACID
- CAS Number:194788-10-8
- Molecular formula:C5H8O3
- Molecular Weight:116.12
4934-99-0
84 suppliers
$21.00/1g
194788-10-8
93 suppliers
$21.00/100mg
Yield: 81%
Reaction Conditions:
with lithium hydroxide monohydrate in tetrahydrofuran;water at 20;
Steps:
3 Example 3
Preparation of cis-3-Hydroxycyclobutylcarboxylic Acid
Methyl cis-3-hydroxycyclobutylcarboxylate prepared in Example 1 (273.3 g, 2.1 mol, 1 eq.) was dissolvedIn H2O/THF (1L/1.5L),Lithium hydroxide monohydrate (218.2 g, 5.2 mol, 2.5 eq.) was then added.Stir overnight at room temperatureWhen the reaction is complete, remove THF.Adjust pH = 4 ~ 5,Then the mixture was extracted with a 4:1 volume ratio of chloroform/isopropanol.Combine the organic phase,Dry and concentrate to get crude product.The crude product was beaten with ethyl acetate/n-heptane,An off-white solid (197.4 g, 1.7 mol) was obtained,For the final product,Yield 81%,97% purity
References:
Shanghai Bilude Pharmaceutical Technology Co., Ltd.;Mi Taoran;Fan Jianjian;Xiong Shichuan;Wu Xunwei CN107903161, 2018, A Location in patent:Paragraph 0033; 0034
480449-99-8
77 suppliers
$15.00/100mg
194788-10-8
93 suppliers
$21.00/100mg