3-hydroxypropanehydrazide synthesis
- Product Name:3-hydroxypropanehydrazide
- CAS Number:24535-11-3
- Molecular formula:C3H8N2O2
- Molecular Weight:104.11
623-72-3
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$15.00/250mg
24535-11-3
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Yield: 79%
Reaction Conditions:
with hydrazine hydrate in methanol;water at 20; for 5 h;Cooling with ice;
Steps:
3.2.3. General Procedure for the Synthesis of Acyl Hydrazides 3a-3k
General procedure: To a stirred solution of esters 2a-2j (70 mmol) in MeOH (30 mL) cooled in an ice-water bath was added dropwise 80% aqueous hydrazine hydrate (6.26 g, 100 mmol). The resulting solution was stirred at room temperature (2a-2b or 2d-2j), or reflux (2c), until the completion of reaction as indicated by TLC analysis (typically within 5 h). The reaction mixture was evaporated on a rotary evaporator to give a residue, which was purified by column chromatography through a short silica gel column to yield 3a-3k after trituration with n-hexane if possible.
References:
Tian, He;Liu, Wei;Zhou, Zhixing;Shang, Qian;Liu, Yuqiang;Xie, Yafei;Liu, Changying;Xu, Weiren;Tang, Lida;Wang, Jianwu;Zhao, Guilong [Molecules,2016,vol. 21,# 11,art. no. 1543]
57-57-8
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$24.73/250mgs:
24535-11-3
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6149-41-3
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$20.00/1g
24535-11-3
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