3-[(methoxycarbonyl)amino]propanoic acid synthesis
- Product Name:3-[(methoxycarbonyl)amino]propanoic acid
- CAS Number:158213-81-1
- Molecular formula:C5H9NO4
- Molecular Weight:147.13
Yield:158213-81-1 36%
Reaction Conditions:
with sodium hydroxide in water at 10 - 20; for 16 h;
Steps:
VIII.VIII-XI.VIII-AX
Example VIII-XIPreparation of Compounds 411-414General Procedure VIII-AXA solution of 3-aminopropionic acid (2 g, 22.47 mmol) in 22 mL of 1N sodium hydroxide solution were cooled to 10° C. Methyl chloroformate (2.12 g, 22.47 mmol) and 11 mL of a 2N NaOH solution were added simultaneously to the cooled mixture. After stirring for 16 h at r.t., the mixture treated with 1N aqueous HCl until a pH of 2 was reached. Subsequently, the mixture was extracted with ethyl acetate (100 mL×3). The extracts were combined, dried over sodium sulfate, filtered and concentrated to yield compound VIII-XIa (1.2 g, yield: 36%) as a white solid.
References:
US2011/152246,2011,A1 Location in patent:Page/Page column 312
77300-42-6
3 suppliers
inquiry
158213-81-1
9 suppliers
inquiry