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β-Alanine

Description Chemical Properties Uses Biological Functions Preparation beta-alanine dosage
β-Alanine
β-Alanine structure
CAS No.
107-95-9
Chemical Name:
β-Alanine
Synonyms
β-Ala;-Alaine;Analine;Abufene;beta-AL;BETA-ALA;NSC 7603;H-BAla-OH;B-ALANINE;FEMA 3252
CBNumber:
CB0711205
Molecular Formula:
C3 H7 N O2
Formula Weight:
89.09
MOL File:
107-95-9.mol

β-Alanine Properties

Melting point:
202 °C (dec.)(lit.)
Boiling point:
237.1±23.0 °C(Predicted)
Density 
1,437 g/cm3
refractive index 
1.4650 (estimate)
FEMA 
3252 | BETA-ALANINE
Flash point:
204-206°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 1 M at 20 °C, clear, colorless
pka
3.55(at 25℃)
form 
Crystalline Powder
color 
White
PH
6.0-7.5
Water Solubility 
Soluble in water(550g/L). Slightly soluble in alcohol. Insoluble in ether and acetone.
Decomposition 
204-206 ºC
λmax
λ: 260 nm Amax: ≤0.02
λ: 280 nm Amax: ≤0.02
JECFA Number
1418
Merck 
14,205
BRN 
906793
Stability:
Stable. Keep dry.
InChIKey
UCMIRNVEIXFBKS-UHFFFAOYSA-N
CAS DataBase Reference
107-95-9(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
BETA-ALANINE
FDA UNII
11P2JDE17B
NIST Chemistry Reference
Beta-alanine(107-95-9)
EPA Substance Registry System
.beta.-Alanine (107-95-9)
SAFETY
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  UA2369200
TSCA  Yes
HS Code  29224920
NFPA 704
0
1 0

β-Alanine price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 05159 β-Alanine BioUltra, ≥99.0% (NT) 107-95-9 100g $62.7 2021-03-22 Buy
Sigma-Aldrich 05159 β-Alanine BioUltra, ≥99.0% (NT) 107-95-9 500g $230 2021-03-22 Buy
TCI Chemical A0180 beta-Alanine >99.0%(T) 107-95-9 25g $17 2021-03-22 Buy
TCI Chemical A0180 beta-Alanine >99.0%(T) 107-95-9 500g $50 2021-03-22 Buy
Alfa Aesar A16665 beta-Alanine, 98% 107-95-9 250g $24.1 2021-03-22 Buy

β-Alanine Chemical Properties,Uses,Production

Description

Beta-alanine is a non-proteogenic amino acid that is produced endogenously in the liver. In addition, humans acquire beta-alanine through the consumption of foods such as poultry and meat. By itself, the ergogenic properties of beta-alanine are limited; however, beta-alanine has been identified as the rate-limiting precursor to carnosine synthesis, and has been consistently shown to increase levels of carnosine in human skeletal muscle. Doses of 4 to 6 g/day of beta-alanine have been shown to increase muscle carnosine concentrations by up to 64 % after 4 weeks, and up to 80 % after 10 weeks. Baguet et al. demonstrated that individuals vary in the magnitude of response to 5 to 6 weeks of betaalanine supplementation (4.8 g/day), with high responders increasing muscle carnosine concentrations by an average of 55 %, and low responders increasing by an average of only 15 %. The difference between high and low responders seems, at least in part, to be related to baseline muscle carnosine content and muscle fiber composition.
Beta-alanine
β-Alanine, a β−amino acid, is a component of pantothenic acid and the rate-limiting amino acid in the biosynthesis of the histidinyl antioxidant dipeptides carnosine and anserine. Endogenous β-amino acid that is a nonselective agonist at glycine receptors and a ligand for the G protein-coupled orphan receptor, TGR7 (MrgD). β-Alanine flux plays a cytoprotective role by supporting the osmotic stability of marine organisms, preimplantation mouse embryos and mammalian cells exposed to hypoxic stress.

Chemical Properties

White powder

Uses

It is widely used in medicine, feed, food, and other industries, mostly to synthesize pantothenic acid and calcium pantothenate (a medicine and feed additive), carnosine, pamidronate sodium, barley nitrogen. It is also used to produce plating corrosion inhibiter, as a biological reagent, and as an organic synthesis intermediate. Used as a food and health supplement additive. Endogenous beta-amino acids, non-selective glycine receptor agonists ,G-protein-coupled orphan receptor (TGR7, MrgD) ligand. Relying on the stability of marine biology, beta-aminopropionic acid has a protective effect on cells.

Biological Functions

β-alanine is a non-essential amino acid that can potentially indirectly enhance performance of extremely high intensity (110% of VO2 peak), short duration (1-5 minutes) bouts of exercise. β-alanine may enhance performance by increasing intramuscular levels of another amino acid, carnosine. It is well established that acidosis can increase fatigue during exercise and therefore increasing the body’s buffering capacity may improve high-intensity, short-duration exercise performance. The importance of carnosine has been previously described by Tallon et al., who reported carnosine concentrations in body builders of 40 mmol/kg dry mass compared to the average human of 16 mmol/kg dry mass. Tallon et al. estimated carnosine to account for 20% of total buffering capacity in body builders compared to 10% in the typical population. In theory, if an athlete of any age increases the amount of carnosine present in skeletal muscle, they can enhance their ability to buffer acidic concentrations during high-intensity exercise and thus delay fatigue.

Preparation

beta-alanine dosage

A common side effect of β-alanine supplementation is paresthesia which is a sensation of tingling, burning, prickling or numbness to a person's skin with no apparent long-term physical effects.
An early investigation reported 10 mg/kg or approximately 800 mg of β-alanine to be the maximal single dose that could be consumed without experiencing significant symptoms of paresthesia. Moreover, β-alanine concentrations peaked 30–40 minutes following consumption and returned to baseline 3 hours following consumption. As a result, an individual supplementing with β-alanine could consume multiple doses throughout the day in 3-hour intervals. In this regard, the consumption of 6.4 g/day of β-alanine consumed in eight doses of 800 mg appears more effective at enhancing skeletal muscle carnosine levels than the consumption of 3.2 g/day of β-alanine consumed in four doses of 800 mg. Finally, controlled release capsules have been developed allowing for the single dose consumption of 1600 mg without the presentation of paresthesia, allowing users to consume fewer daily doses of β-alanine. As a result, masters athletes wishing to experiment with β-alanine should aim to consume 6.4 g/day, which can be accomplished with eight doses of 800 mg of β-alanine, or with four doses of 1600 mg with controlled release β-alanine capsules.

Description

β-Alanine (or beta-alanine) is a naturally occurring beta amino acid, which is an amino acid in which the amino group is at the β- position from the carboxylate group (i.e., two atoms away. The IUPAC name for β-alanine is 3-amino propanoic acid. Unlike its counterpart α-alanine, β-alanine has no stereocenter.
β-Alanine is not used in the biosynthesis of any major proteins or enzymes. It is formed in vivo by the degradation of dihydrouracil and carnosine. It is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (vitamin B5), which itself is a component of coenzyme A. Under normal conditions, β-alanine is metabolized into acetic acid.
β-Alanine is the rate-limiting precursor of carnosine, which is to say carnosine levels are limited by the amount of available β-alanine. Supplementation with β-alanine has been shown to increase the concentration of carnosine in muscles, decrease fatigue in athletes and increase total muscular work done.
Typically, studies have used supplementing strategies of multiple doses of 400 mg or 800 mg, administered at regular intervals for up to eight hours, over periods ranging from 4 to 10 weeks . After a 10 - week supplementing strategy, the reported increase in intramuscular carnosine content was an average of 80.1% (range 18 to 205%).

Chemical Properties

This is a secondary amino acid, which is formed in vivo by the degradation of dihydrouracil and carnosine. Because neuronal uptake and neuronal receptor sensitivity to β-alanine have been demonstrated, the compound may be a false transmitter replacing GABA. A rare genetic disorder, hyper-β-alaninemia, has been reported. It is used as a flavor enhancer, flavoring agent, nutrient supplement or adjuvant. β-Alanine has a slightly sweet taste.

Chemical Properties

White crystalline powder

Occurrence

Reported to occur as a component in amino acids; carnosine, anserine, pantothenic acid

Uses

β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine, as a result supplementation with β-alanine increases the concentration of carnosine in muscles.

Definition

ChEBI: A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.

Preparation

By heating acrylic acid with concentrated aqueous ammonia under pressure, by addition of acrylonitrile to phthalimide or to ammonia; from β-aminopropionitrile, from succinimide by the Hofmann degradation.

Purification Methods

Crystallise β-alanine by dissolving it in a hot saturated aqueous solution, filtering, adding four volumes of absolute EtOH and cooling in an ice-bath. Recrystallise it in the same way and then finally, crystallise it from a warm saturated solution in 50% EtOH and adding four volumes of absolute EtOH with cooling in an ice-bath. The crystals are dried in a vacuum desiccator over P2O5. [Donovan & Kegeles J Am Chem Soc 83 255 1961, Beilstein 4 IV 2526.]

β-Alanine Preparation Products And Raw materials

Raw materials

Preparation Products


β-Alanine Suppliers

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Capot Chemical Co.,Ltd.
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View Lastest Price from β-Alanine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-22 β-Alanine
107-95-9
US $35.00 / KG 1KG 99% 20 tons Hanhong Medicine Technology (Hubei) Co., Ltd.
2021-10-22 β-Alanine
107-95-9
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-10-20 Beta Alanine
107-95-9
US $90.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

β-Alanine Spectrum


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