3-METHYL-1-PYRIDIN-2-YL-PIPERAZINE synthesis
1synthesis methods
- Product Name:3-METHYL-1-PYRIDIN-2-YL-PIPERAZINE
- CAS Number:63286-11-3
- Molecular formula:C10H15N3
- Molecular Weight:177.25
Yield:63286-11-3 54%
Reaction Conditions:
Stage #1: (RS)-2-methylpiperazinewith [2,2]bipyridinyl;nickel diacetate;sodium hydride;tert-Amyl alcohol in tetrahydrofuran at 65; for 2 h;
Stage #2: 2-chloropyridinewith styrene in tetrahydrofuran at 65; for 8.5 h;
References:
Brenner, Eric;Schneider, Rapha?l;Fort, Yves [Tetrahedron,2002,vol. 58,# 34,p. 6913 - 6924]