3-methyl-2-nitrobenzoyl chloride synthesis
- Product Name:3-methyl-2-nitrobenzoyl chloride
- CAS Number:50424-93-6
- Molecular formula:C8H6ClNO3
- Molecular Weight:199.59
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Yield:50424-93-6 100%
Reaction Conditions:
with thionyl chloride;N,N-dimethyl-formamide in 1,2-dichloro-ethane; for 3 h;Reflux;
Steps:
1.1 (1) Synthesis of 2-nitro-3-methylbenzoyl chloride
2-nitro-3-methylbenzoic acid (10.0 g, 0.055 mol), dichloroethane (200 ml), chlorosulfoxide (23.8 g, 0.2 mol), and DMF (1 drop) were sequentially added to a 250 ml single-necked flask, heated to reflux and reacted for 3 h.
Then, the solvent was removed under elevated pressure to obtain a brown liquid (11.0 g, yield 100%).
The product was directly used in next step without further post-treatment.
References:
US2020/329707,2020,A1 Location in patent:Paragraph 0039-0040; 0053-0054
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