3-Methyl-3-phenyl-butanal synthesis
- Product Name:3-Methyl-3-phenyl-butanal
- CAS Number:6325-41-3
- Molecular formula:C11H14O
- Molecular Weight:162.23
![Benzene, [1-(ethenyloxy)-1-methylethyl]-](/CAS/20210305/GIF/22881-48-7.gif)
22881-48-7
6325-41-3
In a 20 mL two-necked flask, (μ3,η2,η3,η5-aceene)Ru3(CO)7 (1 or 0.1 mol% relative to vinyl ether) was dissolved in a minimal amount of anhydrous dioxane. Hydrogen-containing silane (10 to 30 mol% relative to the vinyl ether) was added to this solution and the mixture was stirred at 50°C for 30 minutes. A gradual darkening of the initial orange color of the solution was observed. Subsequently, vinyl ether was added dropwise and the mixture was continued to be stirred at 50°C. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using hexane/EtOAc as eluent to give the final target product 3-methyl-3-phenylbutyraldehyde.
1010-48-6
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6325-41-3
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Yield:6325-41-3 88 %Spectr.
Reaction Conditions:
Stage #1: 3-methyl-3-phenylbutanoic acidwith 2,6-dimethylpyridine;nickel(II) bromide trihydrate;4,4'-di-tert-butyl-2,2'-bipyridine;zinc;dimethyl dicarbonate in ethyl acetate; for 0.25 h;Inert atmosphere;Green chemistry;
Stage #2: with diphenylsilane in ethyl acetate at 40; for 24 h;Inert atmosphere;Green chemistry;
References:
Iosub, Andrei V.;Morav?ík, ?tefan;Wallentin, Carl-Johan;Bergman, Joakim [Organic Letters,2019,vol. 21,# 19,p. 7804 - 7808] Location in patent:supporting information
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6325-41-3
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6325-41-3
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2629-47-2
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556-82-1
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6325-41-3
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515-40-2
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6325-41-3
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