3-methyl-4-nitro-1H-indole synthesis
- Product Name:3-methyl-4-nitro-1H-indole
- CAS Number:134271-94-6
- Molecular formula:C9H8N2O2
- Molecular Weight:176.17
134271-93-5
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134271-94-6
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133053-76-6
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$505.43/5MG
Yield:133053-76-6 86%
Reaction Conditions:
in phosphoric acid;toluene;
Steps:
1 3-Methyl-4-nitro-1H-indole and 3-Methyl-6-nitro-1H-indole
3-Methyl-4-nitro-1H-indole and 3-Methyl-6-nitro-1H-indole A mixture of N-(3-nitro-phenyl)-N'-propylidene-hydrazine dissolved in 85% H3PO4 (20 mL) and toluene (20 mL) was heated at 90-100° C. for 2 h. After cooling, toluene was removed under reduced pressure. The resultant oil was basified with 10% NaOH to pH 8. The aqueous layer was extracted with EtOAc (100 mL*3). The combined organic layers were dried, filtered and concentrated under reduced pressure to afford a mixture of 3-methyl-4-nitro-1H-indole and 3-methyl-6-nitro-1H-indole (1.5 g, 86% over two steps), which was used directly in the next step.
References:
US2011/98311,2011,A1
134271-93-5
0 suppliers
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134271-94-6
23 suppliers
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133053-76-6
48 suppliers
$505.43/5MG
134271-93-5
0 suppliers
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134271-94-6
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99-09-2
20 suppliers
$14.00/1g
134271-94-6
23 suppliers
inquiry
99-09-2
20 suppliers
$14.00/1g
134271-94-6
23 suppliers
inquiry
133053-76-6
48 suppliers
$505.43/5MG