3-(Methylsulfonyl)propanal synthesis
- Product Name:3-(Methylsulfonyl)propanal
- CAS Number:1177282-04-0
- Molecular formula:C4H8O3S
- Molecular Weight:136.17
2058-49-3
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Yield:1177282-04-0 28.41%
Reaction Conditions:
with Dess-Martin periodane in dichloromethane at 25; for 2 h;
Steps:
I.1 Intermediate compound 66:
To a solution of 3 -methyl sulfonylpropan-l-ol compound 1 (5 g, 36.18 mmol, 1 eq) in DCM (50 mL) was added the Dess Martin periodinane (18.42 g, 43.42 mmol, 13.44 mL, 1.2 eq). The reaction was stirred at 25 °C for 2 hr. The reaction mixture was filtered and concentrate under vacuum. The residue was purified by silica gel column chromatography (ethyl acetate 100%) to give the 3 -methyl sulfonylpropanal (1.4 g, 28.41% yield) as a yellow liquid. 1HNMR (400 MHz, CHLOROFORM-d) d ppm 9.93 - 9.72 (m, 1H), 3.45 - 3.29 (m, 2H), 3.22 - 3.05 (m, 2H), 3.04 - 2.93 (m, 3H)
References:
WO2021/170797,2021,A1 Location in patent:Page/Page column 134; 169-170
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