3-N-CBZ-AMINOMETHYLANILINE synthesis

3synthesis methods

Product Name:3-N-CBZ-AMINOMETHYLANILINE
CAS Number:374554-26-4
Molecular formula:C15H16N2O2
Molecular Weight:256.3

4403-70-7 Synthesis

4403-70-7
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501-53-1
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374554-26-4
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Yield:374554-26-4 71%

Reaction Conditions:

with triethylamine in tetrahydrofuran at 0 - 20; for 0.5 h;

Steps:

66A

66A : (3-Amino-benzyl)-carbamic acid benzyl ester; [00502] To a solution of 3-aminobenzylamine (610 mg, 5 mmol) and TEA(1.01 g, 10 mmol) in 10 mL of THF at 0 ⁰C, was added ben∑yl chloroformate (936 mg, 5.5 mmol) dropwise. The mixture was stirred at rt for 30 min. The reaction was quenched with water and extracted with EtOAc (3 x 20 mL). The organic layer was washed with brine, dried (Na₂SO₄O and concentrated. Purification via flash chromatography (0 to 50 % EtOAc in hexanes) gives 66A (911 mg, 71 %). MS (ESI) m/z 257.3 (M+H)⁺.

References:

WO2007/76431,2007,A1 Location in patent:Page/Page column 220-221

Carbamic acid, N-[(3-nitrophenyl)methyl]-, phenylmethyl ester

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374554-26-4
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References

26177-43-5 Synthesis

26177-43-5
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374554-26-4
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References